Viral vectors for therapy of neurologic diseases

Gene therapy using viral vectors for acute neurologic insults.

Enormous knowledge has emerged concerning the cellular and molecular events underlying necrotic neuron death after seizure, hypoxia-ischemia, or hypoglycemia. This has allowed the design of rational therapies to protect neurons at such times. One of the most exciting arenas of such interventions is the use of viral vectors to deliver neuroprotective genes. This review considers the progress in ...

Barriers and recent advances in non-viral vectors targeting the lungs for cystic fibrosis gene therapy

Cystic fibrosis (CF) is an autosomal recessive disorder caused by mutations in CFTR genes that affect chloride ion channel. The CF is a good nominee for gene therapy as the asymptomatic carriers are phenotypically normal, and the desired cells are accessible for vector delivery. Gene therapy shows promising effects involving the correction of gene or replacement of the mutant gene with the func...

18 Viral Vectors for Gene Therapy

Novel viral vectors in infectious diseases

Since the development of vaccinia virus as a vaccine vector in 1984, the utility of numerous viruses in vaccination strategies has been explored. In recent years, key improvements to existing vectors such as those based on adenovirus have led to significant improvements in immunogenicity and efficacy. Furthermore, exciting new vectors that exploit viruses such as cytomegalovirus (CMV) and vesic...

Prospects for therapy of HIV-associated neurologic diseases.

In June 1996, NINDS and Johns Hopkins University Department of Neurology organized a 1‰ day workshop, `HIV Neurologic Therapies Workshop'. The principal objective of the Workshop was to facilitate the development of innovative therapeutic strategies for dementia, neuropathy, neurologic CMV disease, and progressive multifocal leukoencephalopathy (PML). Separate groups focused on different neurol...